Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

All-or-none excitatory postsynaptic potentials in the rat visual cortex

M Volgushev1, L L Voronin, M Chistiakova

  • 1Max Planck Institute for Brain Research, Frankfurt/Main, Germany.

The European Journal of Neuroscience
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bench-scale solid-state fermentation of digested sewage sludge to produce Bacillus thuringiensis: influence of digestate characteristics.

Journal of environmental management·2025
Same author

Valorisation of biowaste digestate through solid state fermentation to produce biopesticides from Bacillus thuringiensis.

Waste management (New York, N.Y.)·2019
Same author

Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred.

The journal of prevention of Alzheimer's disease·2019
Same author

A new paradigm for waste management of organic materials.

Waste management (New York, N.Y.)·2015
Same author

The nucleus raphe magnus OFF-cells are involved in diffuse noxious inhibitory controls.

Experimental neurology·2014
Same author

Modulation of synaptic transmission by adenosine in layer 2/3 of the rat visual cortex in vitro.

Neuroscience·2013
Same journal

Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.

The European journal of neuroscience·2026
Same journal

Topography of Regional Cerebral GABA<sub>A</sub> Receptor Availability in Parkinson's Disease Patients With Freezing of Gait.

The European journal of neuroscience·2026
Same journal

Enhanced Time-Locked Decoding for Spoken Words but Not Environmental Sounds in Natural-Like Auditory Conditions.

The European journal of neuroscience·2026
Same journal

Learning Dynamics in Biophysical Spiking Network Models Are Shaped by KCC2/NKCC1 Cotransporter Stoichiometry.

The European journal of neuroscience·2026
Same journal

Dopamine Receptor Agonism in the Nucleus Accumbens Shell During Aversive Learning or Memory Retrieval: Differential Effects Depending on the Degree of Sugar Familiarity.

The European journal of neuroscience·2026
Same journal

Training in the Categorization of Aerial and Terrestrial Scenes Differentially Impacts Scene-Selective and Nonscene-Selective Regions in Occipitotemporal Cortex.

The European journal of neuroscience·2026
See all related articles

Single-fiber inputs to rat visual cortex neurons exhibit highly reliable, large excitatory postsynaptic potentials (EPSPs). Synaptic release probability can be modulated, altering transmission efficacy and regulating neural circuit gain.

Area of Science:

  • Neuroscience
  • Synaptic transmission

Background:

  • Supragranular neurons in the rat visual cortex receive inputs from single fibers.
  • Excitatory postsynaptic potentials (EPSPs) are crucial for neuronal communication.

Purpose of the Study:

  • To investigate the properties of single-fiber excitatory inputs to supragranular neurons in the rat visual cortex.
  • To understand the mechanisms underlying synaptic transmission reliability and its regulation.

Main Methods:

  • Intracellular recordings from supragranular neurons in rat visual cortex slices.
  • Minimal, presumably single-fiber stimulation to evoke EPSPs.
  • Analysis of EPSP amplitude, variance, and response to paired-pulse and low-frequency stimulation, as well as changes in extracellular Mg2+ concentration.

Related Experiment Videos

Main Results:

  • A subset of cells displayed large (0.5-1.6 mV) EPSPs with remarkably low amplitude variance, near noise levels.
  • These reliable EPSPs were reduced by paired-pulse/low-frequency stimulation or increased extracellular Mg2+.
  • EPSP behavior shifted from all-or-none to fluctuating amplitudes, or vice versa, indicating subunit composition and variable release probabilities.
  • Synaptic release probabilities were shown to switch between high and low values.

Conclusions:

  • Single-fiber inputs to supragranular neurons can exhibit high synaptic efficiency and low variance.
  • Synaptic release probability is dynamically regulated, impacting transmission efficacy.
  • Modulation of release probability serves as a mechanism for regulating synaptic transmission gain in neural circuits.