Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaphylactic shock: mechanisms and treatment

A F Brown1

  • 1Department of Emergency Medicine, Royal Brisbane Hospital, Queensland, Australia.

Journal of Accident & Emergency Medicine
|June 1, 1995
PubMed
Summary

Anaphylactic shock involves complex immune and cellular events triggering mediator release. Prompt treatment with oxygen, fluids, and adrenaline is crucial for managing cardiovascular collapse.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outbreeding Depression as a Cost of Dispersal in the Harpacticoid Copepod, Tigriopus californicus.

The Biological bulletin·2018
Same author

Interdisciplinary dissemination and implementation research to advance translational science: Challenges and opportunities.

Journal of clinical and translational science·2017
Same author

Author reply.

Internal medicine journal·2015
Same author

Icatibant in angiotensin-converting enzyme (ACE) inhibitor-associated angioedema.

Internal medicine journal·2015
Same author

A methyl methacrylate-silica replica technique for electron microscopy.

Nature·2010
Same author

Genito mammary paraffin oil granulomas in the male.

Annals of western medicine and surgery·2010

Area of Science:

  • Immunology
  • Pharmacology
  • Physiology

Background:

  • Anaphylactic shock is a severe, life-threatening allergic reaction.
  • Understanding its complex mechanisms is vital for effective management.

Purpose of the Study:

  • To review the mechanisms of anaphylactic shock.
  • To examine the roles of mediators in cardiovascular collapse.
  • To discuss current and developing treatment strategies.

Main Methods:

  • Review of immunoglobulin and non-immunoglobulin triggering events.
  • Analysis of cellular events and mediator release (cyclic AMP, calcium, arachidonic acid metabolism).
  • Examination of mediator roles in cardiovascular collapse.

Main Results:

  • Anaphylaxis involves primary and secondary mediators, including those from arachidonic acid metabolism.
  • Cardiovascular collapse is a key complication driven by these mediators.
  • Intravenous adrenaline is the primary treatment, with antihistamines and steroids having a limited role.

Conclusions:

  • Anaphylactic shock results from intricate cellular and mediator cascades.
  • Effective management relies on prompt administration of oxygen, fluids, and intravenous adrenaline.
  • Ongoing research aims to develop novel therapeutic agents for anaphylaxis.

Related Experiment Videos