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Spectral editing with adiabatic pulses

R A de Graaf1, Y Luo, M Terpstra

  • 1Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis 55455, USA.

Journal of Magnetic Resonance. Series B
|November 1, 1995
PubMed
Summary
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Adiabatic pulses improve magnetic resonance imaging by ensuring uniform flip angles, even with B1 inhomogeneity. This study converts standard lactate editing sequences into adiabatic versions, enhancing in vivo surface-coil studies.

Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Spectroscopy
  • Nuclear Magnetic Resonance

Background:

  • Adiabatic pulses offer uniform flip angles despite B1 inhomogeneity, crucial for in vivo surface-coil MRI.
  • Conventional spectral-editing sequences can be limited by B1 inhomogeneity.

Purpose of the Study:

  • To convert conventional square pulse-based spectral-editing sequences into adiabatic counterparts.
  • To evaluate adiabatic sequences for lactate editing in Magnetic Resonance Imaging (MRI).

Main Methods:

  • Development and experimental evaluation of eight adiabatic homo- and heteronuclear sequences.
  • Application of sequences for lactate editing in biological samples.

Main Results:

Related Experiment Videos

  • Gradient-enhanced multiple-quantum-coherence filtering achieved 100% signal recovery and excellent water/lipid suppression for homonuclear lactate editing.
  • Gradient-enhanced heteronuclear multiple-quantum-coherence filtering provided superior signal suppression for heteronuclear [3-(13)C]lactate editing.
  • J-modulated spin-echo sequences demonstrated maximum sensitivity for heteronuclear lactate editing.

    • Conclusions:

    • Adiabatic pulse technology enhances spectral editing for lactate detection in MRI.
    • Gradient-enhanced multiple-quantum-coherence filtering and J-modulated spin-echo sequences offer distinct advantages for homonuclear and heteronuclear lactate editing, respectively.