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Related Experiment Videos

Morphine-induced deficits in sleep patterns: attenuation by glucose

G Arankowsky-Sandoval1, P E Gold

  • 1Department of Psychology, University of Virginia, Charlottesville 22903, USA.

Neurobiology of Learning and Memory
|September 1, 1995
PubMed
Summary

Glucose administration can counteract morphine-induced sleep disturbances in rats. This study shows glucose reverses morphine

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Sleep Science

Background:

  • Morphine's effects on neural and behavioral measures can be reduced by elevated glucose levels.
  • Previous research indicates glucose can attenuate morphine's impact on learning and memory.

Purpose of the Study:

  • To investigate glucose's ability to mitigate sleep deficits caused by morphine in rats.
  • To explore the dose-dependent effects of glucose in reversing morphine-induced sleep alterations.

Main Methods:

  • Systemic injections of morphine and glucose were administered to rats.
  • Different doses of morphine (1 mg/kg and 10 mg/kg) were used to induce sleep deficits.
  • Concomitant administration of glucose (100 mg/kg and 250 mg/kg) was employed to assess its protective effects.

Main Results:

  • A low dose of morphine (1 mg/kg) moderately decreased slow-wave sleep, an effect prevented by 100 mg/kg glucose.
  • A high dose of morphine (10 mg/kg) significantly delayed the onset of both slow-wave sleep and REM sleep.
  • Concurrent glucose administration attenuated these morphine-induced sleep delays.

Conclusions:

  • Glucose administration effectively reverses morphine-induced sleep deficits in rats.
  • The findings extend the known glucose reversals of morphine's effects to include sleep measures.
  • This suggests a potential role for glucose in managing opiate-induced sleep disturbances.

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