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Effect of apolipoprotein E polymorphism on fasting retinyl palmitate level
A P Surguchov1, E Boerwinkle, A R Sharrett
1Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Biochemical and Molecular Medicine
|August 1, 1995
Summary
Apolipoprotein E (apo E) genotypes significantly impact fasting retinyl palmitate (RP) levels in individuals with carotid artery thickening. This effect was not observed in control subjects, suggesting a role in remnant clearance.
Area of Science:
- Cardiovascular Science
- Genetics
- Nutritional Science
Background:
- Apolipoprotein E (apo E) is crucial for lipid metabolism and transport.
- Common apo E genotypes are associated with various health conditions.
- Retinyl palmitate (RP) is a form of Vitamin A, and its levels can reflect lipid metabolism.
Purpose of the Study:
- To investigate the association between common apolipoprotein E (apo E) genotypes and fasting retinyl palmitate (RP) levels.
- To determine if this association differs between individuals with carotid artery intimal thickening and controls.
Main Methods:
- A study involving 344 white individuals, comprising 130 cases with carotid artery intimal thickening and 214 controls.
- Analysis of fasting retinyl palmitate (RP) levels in relation to common apo E genotypes.
Main Results:
- Common apo E genotypes had a statistically significant effect on fasting RP levels in cases (individuals with carotid artery intimal thickening).
- The effect of common apo E genotypes on fasting RP levels was not statistically significant in the control group.
- Other traits may interact with apo E genotype to influence fasting RP levels in cases.
Conclusions:
- Apolipoprotein E (apo E) genotype influences fasting retinyl palmitate (RP) levels, particularly in individuals with carotid artery intimal thickening.
- The mechanism may involve the remnant clearance particle pathway.
- Gene-environment interactions are suggested to play a role in cases.