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Published on: November 30, 2021
Metabolic and infectious disorders associated with emesis in infants
1Department of Pediatrics, Sunrise Children's Hospital, Las Vegas, NV, USA.
Insights
This review details the pathophysiology of infant vomiting, covering symptoms, history, physical exam findings, and laboratory tests. It also discusses therapeutic interventions for vomiting in infants due to infectious and metabolic disorders.
Area of Science:
- Pediatrics
- Gastroenterology
Background:
- Vomiting in infants is a common symptom with diverse underlying causes, ranging from infections to metabolic disorders.
- The signs and symptoms of infant vomiting often overlap, making diagnosis challenging.
Purpose of the Study:
- To review the pathophysiological mechanisms of vomiting in infants.
- To describe the signs and symptoms associated with infant vomiting.
- To outline diagnostic and therapeutic approaches for vomiting in infants.
Main Methods:
- Review of pertinent historical perspectives including prenatal, neonatal, medication, exposure, and family history.
- Examination of specific physical findings relevant to infant vomiting assessment.
- Discussion of essential laboratory tests for evaluating vomiting infants.
- Overview of therapeutic interventions for infectious and metabolic causes of infant vomiting.
Main Results:
- Infant vomiting stems from various medical and surgical conditions.
- Comprehensive patient history and physical examination are crucial for diagnosis.
- Laboratory tests aid in assessing illness severity and guiding specimen collection.
- Effective management involves specific and supportive therapies tailored to the underlying cause.
Conclusions:
- Understanding the pathophysiology, clinical presentation, and diagnostic tools is vital for managing infant vomiting.
- A systematic approach incorporating history, physical examination, and laboratory data is essential.
- Appropriate therapeutic interventions can improve outcomes for infants experiencing vomiting.
Abstract:
Vomiting is associated with an endless array of medical and surgical conditions, including infectious and metabolic disorders. This article is designed to review the pathophysiological mechanism of vomiting in infants. There is tremendous overlap in the signs and symptoms associated with vomiting in infancy, and these will be described. Pertinent historical prospectives are examined including prenatal history, neonatal history, underlying conditions, recent or chronic medication usage, exposures to illnesses or toxin, and family history. Specific findings obtained during physical examination may help direct further assessment of the vomiting infant. Laboratory tests are essential to the evaluation of the infant with emesis. These studies serve not only to help assess the severity of illness in the vomiting infant, but also to aid in the appropriate collection and handling of specimens during the time of critical presentation that may be useful during what are often complex and confusing clinical courses. Therapeutic interventions including both specific and supportive modalities for infants with vomiting caused by infectious and metabolic disorders are discussed.
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