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Synthesis of mannostatins A and B from myo-inositol
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Bioorganic & Medicinal Chemistry
|July 1, 1995
Abstract:
Mannostatins A and B, along with the respective enantiomer and diastereoisomer having the (S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean alpha-mannosidase was measured, revealing that the 4-aminocyclopentane-1,2,3-triol structure plays a major role in interaction with the enzyme.