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A genetic map of chromosome 11q, including the atopy locus
A J Sandford1, M F Moffatt, S E Daniels
1Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
European Journal of Human Genetics : EJHG
|January 1, 1995
Abstract:
Atopy is a common and genetically heterogeneous syndrome predisposing to allergic asthma and rhinitis. A locus linked to the atopy phenotype has been shown to be present on chromosome 11q12-13. Linkage has only been seen in maternally derived alleles. We have constructed a genetic linkage map of the region, using 15 markers to span approximately 27 cM, and integrate previously published maps. Under a model of maternal inheritance, the atopy locus is placed within a 7-cM interval between D11S480 and D11S451. The interval contains the important candidate gene FCERIB.