Jove
Visualize
Contact Us

Related Experiment Videos

Muscle development. Making Drosophila muscle

M V Taylor1

  • 1Department of Zoology, University of Cambridge, UK.

Current Biology : CB
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation.

Experimental neurology·2016
Same author

Psychosocial impact of heart transplantation on spouses.

Clinical nursing research·2002
Same author

Muscle development: molecules of myoblast fusion.

Current biology : CB·2000
Same author

Drosophila dumbfounded: a myoblast attractant essential for fusion.

Cell·2000
Same author

A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA.

Developmental biology·2000
Same author

Different levels, but not different isoforms, of the Drosophila transcription factor DMEF2 affect distinct aspects of muscle differentiation.

Developmental biology·1999
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Researchers identified the D-mef2 transcription factor as a key controller of muscle cell differentiation in flies. This discovery marks the first gene found to regulate multiple muscle cell types.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Muscle development is crucial for organismal function.
  • Understanding the genetic regulation of muscle differentiation is essential.

Purpose of the Study:

  • To identify genes controlling muscle cell differentiation in Drosophila.
  • To characterize the role of the D-mef2 gene in this process.

Main Methods:

  • Analysis of Drosophila melanogaster (fruit fly) mutants.
  • Investigating gene expression and protein function.

Main Results:

  • The D-mef2 transcription factor was identified as a critical regulator.
  • D-mef2 controls differentiation in multiple distinct muscle cell types.

Related Experiment Videos

  • This is the first described gene with this broad regulatory function.

    • Conclusions:

    • D-mef2 plays a fundamental role in muscle development.
    • The discovery of D-mef2 provides new insights into the genetic control of myogenesis.