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The acute-phase response

B H Pannen1, J L Robotham

  • 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA.

New Horizons (Baltimore, Md.)
|May 1, 1995
PubMed
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The acute-phase response involves liver-synthesized proteins that change during inflammation and injury. Understanding these complex regulatory mechanisms could lead to new therapeutic strategies for injury response.

Area of Science:

  • Biochemistry
  • Immunology
  • Molecular Biology

Background:

  • Inflammation and tissue injury trigger significant alterations in plasma protein concentrations.
  • These proteins, known as acute-phase proteins (APPs), are primarily synthesized by the liver.
  • The acute-phase response is a complex biological process involving various signaling mediators.

Purpose of the Study:

  • To elucidate the intricate regulatory mechanisms governing the acute-phase response.
  • To explore the transcriptional and post-transcriptional regulation of acute-phase protein gene expression.
  • To investigate the in vivo functions and diagnostic value of acute-phase proteins.

Main Methods:

  • Analysis of mediator-receptor interactions on hepatocytes.
  • Investigation of signal transduction pathways affecting gene expression.

Related Experiment Videos

  • Examination of transcriptional and post-transcriptional regulatory mechanisms.
  • Assessment of acute-phase protein plasma concentrations in clinical conditions.

    • Main Results:

    • Mediators exhibit complex synergistic or inhibitory effects on APP gene expression.
    • Gene expression changes are primarily transcriptionally regulated, with potential post-transcriptional involvement.
    • Some APPs contribute to tissue repair and hemostasis, but functions of others remain unclear.
    • APP plasma levels hold diagnostic and prognostic significance in certain clinical scenarios.

    Conclusions:

    • The acute-phase response is a highly regulated process involving complex mediator interactions.
    • Further research into regulatory mechanisms can inform therapeutic strategies for injury.
    • Characterizing APP functions is crucial for understanding their role in healing and disease.