Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Heat shock and tissue protection

G A Perdrizet¹

¹Department of Surgery, Hartford Hospital, CT 06102-5037, USA.

New Horizons (Baltimore, Md.)

|May 1, 1995

Summary

Inducing a heat-shock response before organ preservation can protect tissues from ischemia and reperfusion injuries. This targeted cellular stress response offers a novel protective strategy for organ transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chronic Diseases as Barriers to Oxygen Delivery: A Unifying Hypothesis of Tissue Reoxygenation Therapy.

Advances in experimental medicine and biology·2017

Same author

Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?

Advances in experimental medicine and biology·2016

Same author

Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response.

Cell stress & chaperones·2001

Same author

Tissue-level cytoprotection.

Cell stress & chaperones·2001

Same author

Babesiosis in a renal transplant recipient acquired through blood transfusion.

Transplantation·2000

Same author

Surgical stress and the heat shock response: in vivo models of stress conditioning.

Annals of the New York Academy of Sciences·1999

Area of Science:

Cellular Biology
Transplantation Medicine
Physiology

Background:

Ischemia and reperfusion (I/R) injury is a significant challenge in various clinical conditions, including trauma and myocardial infarction.
Organ preservation for transplantation involves stressful conditions that lead to I/R injury.
The cellular response to heat, known as the heat-shock response, provides temporary protection against various stressors.

Purpose of the Study:

To investigate the potential of inducing a heat-shock response to protect organs from I/R injury during preservation and transplantation.
To explore the generalized stress response mechanism in the context of organ preservation.

Main Methods:

Induction of the heat-shock response in whole organs prior to procurement.
Evaluation of tissue protection against preservation (ischemia) and transplantation (reperfusion) injuries.

Main Results:

Purposeful induction of the heat-shock response demonstrated successful protection of organs.
Tissues subjected to the heat-shock response exhibited reduced susceptibility to I/R injuries.

Conclusions:

The heat-shock response can be a viable preventive intervention against organ injury during preservation and transplantation.
Targeting cellular stress responses offers a promising avenue for improving organ viability and transplant outcomes.

Related Experiment Videos