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Related Experiment Videos

Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in

K Ojima1, K Matsumoto, M Tohda

  • 1Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.

Brain Research
|June 26, 1995
PubMed
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Social isolation in mice reduces pentobarbital

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Social isolation is known to induce behavioral and physiological changes.
  • The central noradrenergic and corticotropin-releasing factor (CRF) systems play roles in stress and behavior.
  • Pentobarbital is a widely used anesthetic and hypnotic agent.

Purpose of the Study:

  • To investigate the modulatory effects of central noradrenergic and CRF systems on pentobarbital-induced hypnosis in socially isolated mice.
  • To explore the relationship between social isolation, aggression, and hypnotic response.

Main Methods:

  • Social isolation of mice for varying durations.
  • Administration of pentobarbital to assess hypnotic activity (sleeping time).
  • Intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) administration of CRF, yohimbine, alpha-helical CRF9-41 (alpha hCRF), clonidine, propranolol, and prazosin.

Related Experiment Videos

  • Assessment of intermale aggressive behavior in isolated mice.

    • Main Results:

    • Pentobarbital-induced sleeping time decreased with longer isolation periods, correlating with increased aggressive behavior.
    • CRF and yohimbine (alpha 2-antagonist) reduced hypnotic activity in group-housed mice but not in isolated mice.
    • Alpha hCRF (CRF antagonist) and clonidine (alpha 2-agonist) restored pentobarbital's hypnotic activity in isolated mice.
    • Propranolol (beta-antagonist) and prazosin (alpha 1-antagonist) dose-dependently recovered pentobarbital's hypnotic activity in isolated mice.

    Conclusions:

    • The noradrenergic and CRF systems are involved in the altered hypnotic response to pentobarbital following social isolation.
    • Alpha-1, alpha-2, and beta-adrenergic receptor systems, as well as the CRF system, modulate the effects of social isolation on pentobarbital-induced hypnosis.
    • These findings suggest potential therapeutic targets for managing behavioral and sleep disturbances associated with social isolation.