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NUVIEW: software for display and interactive manipulation of nucleic acid models

M Bansal1, D Bhattacharyya, S Vijaylakshmi

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

Computer Applications in the Biosciences : CABIOS
|June 1, 1995
PubMed
Summary

NUVIEW software visualizes skeletal models of double helical nucleic acids, enabling interactive 3D manipulation for understanding DNA/RNA structure and function.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Molecular Modeling

Background:

  • Understanding the three-dimensional structure of nucleic acids is crucial for elucidating their biological functions.
  • Visualizing complex DNA and RNA structures aids in analyzing sequence-structure-function relationships.

Purpose of the Study:

  • To introduce the NUVIEW software package for interactive visualization and manipulation of nucleic acid skeletal models.
  • To facilitate the analysis of nucleic acid topology, sequence features, and spatial relationships.

Main Methods:

  • Development of the NUVIEW software for generating and displaying skeletal models of double helical nucleic acids.
  • Implementation of interactive keyboard-controlled rotations, translations, and scaling transformations.
  • Inclusion of residue identification, distance measurement, and sequence-based color-coding features.

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Main Results:

  • NUVIEW allows real-time interactive manipulation of large DNA/RNA double helices.
  • The software aids in tracing nucleic acid chain paths, identifying topological features, and locating specific regions.
  • Sequence repeats and distances between residues can be easily identified and quantified.

Conclusions:

  • NUVIEW provides a valuable tool for researchers to visualize and analyze nucleic acid structures in 3D.
  • Interactive manipulation enhances the understanding of the interplay between base sequence, structure, and biological activity.
  • The software can assist in the study of DNA/RNA topology and the spatial organization of genetic material.