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Updated: Aug 11, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Screening for colorectal cancer
1School of Public Health, University of Minnesota, Minneapolis 55455, USA.
Abstract:
This paper reviews studies on fecal occult blood testing and sigmoidoscopy screening for colorectal cancer. Recently published data from a randomized controlled trial provides the first concrete evidence that annual screening for fecal occult blood can reduce colorectal cancer mortality by at least 33%. These results are corroborated by a nonrandomized but controlled study that showed a 43% colorectal cancer mortality reduction with early detection through fecal occult blood testing and sigmoidoscopy, and by a case-control study that showed a 31% colorectal cancer mortality reduction associated with fecal occult blood testing. Persuasive data to support screening recommendations for sigmoidoscopy are not yet available; however, results from observational studies are suggestive and should stimulate further research to assess the benefit of sigmoidoscopy screening.
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