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Updated: Jul 16, 2026

Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth

J Wang1, Q Lin, H Langston

  • 1Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham 35294, USA.

Immunity
|October 1, 1995
PubMed

Type 1 interferons alpha and beta are found to be potent inhibitors of IL-7-induced growth of early B lineage cells, while having no effect on cell growth induced by IL-2, IL-3, IL-4, or autogenous factors. The combination of IL-7 and interferons alpha/beta induces bcl-2 down-regulation and cell death by apoptosis. These conclusions were derived initially from experiments employing exogenous cytokines, but functional type 1 interferons are also shown to be produced by resident bone marrow macrophages. As physiological modulators of IL-7-driven proliferation and cell survival, interferons alpha/beta may cooperate with other homeostatic factors to maintain the balanced production of normal B lineage cells.

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