Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GeneQuiz: a workbench for sequence analysis

M Scharf1, R Schneider, G Casari

  • 1Protein Design Group, European Molecular Biology Laboratory, Heidelberg, Germany.

Proceedings. International Conference on Intelligent Systems for Molecular Biology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin network markers of leukemia.

Bioinformatics (Oxford, England)·2020
Same author

Neoantigen prediction and computational perspectives towards clinical benefit: recommendations from the ESMO Precision Medicine Working Group.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

A systematic review and trial sequential analysis of intravenous vs. oral peri-operative paracetamol.

Anaesthesia·2020
Same author

Development of pipette tip-based poly(methacrylic acid-co-ethylene glycol dimethacrylate) monolith for the extraction of drugs of abuse from oral fluid samples.

Talanta·2019
Same author

Women's interest in a personal breast cancer risk assessment and lifestyle advice at NHS mammography screening.

Journal of public health (Oxford, England)·2016
Same author

Measurement of the relative prompt production rate of <i>χ</i><sub>c2</sub> and <i>χ</i><sub>c1</sub> in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same journal

Proceedings of the 8th International Conference on Intelligent Systems for Molecular Biology (ISMB 2000). San Diego, California, USA. August 19-23, 2000.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2001
Same journal

Analysis of gene expression data with pathway scores.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Mining for putative regulatory elements in the yeast genome using gene expression data.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Sequence database search using jumping alignments.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
See all related articles

GeneQuiz is a new software system for large-scale biological sequence analysis. It automates repetitive tasks and accelerates the analysis of protein sequences, improving functional characterization.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Computational sequence analysis presents significant cognitive challenges.
  • Large-scale analysis of biological sequences, such as protein sequences, requires efficient tools.
  • Previous experience with yeast chromosome III protein sequence analysis informed system design.

Purpose of the Study:

  • To present the prototype of the GeneQuiz software system.
  • To address the needs of computational sequence analysis.
  • To model the sequence analysis process and overcome cognitive challenges.

Main Methods:

  • Developed a two-part system: a database update/search system and a visualization/browsing system.
  • Utilized Perl programs and RDB for the database component.

Related Experiment Videos

  • Employed C++/ET++ for the visualization and browsing component.
  • Focused on automating repetitive tasks like database updates and similarity searches.

    • Main Results:

    • The system automates repetitive actions in sequence analysis.
    • Hit-lists summarize results from heterogeneous database searches.
    • Uniform relational tables and browsing mechanisms accelerate functional characteristic extraction.
    • Indexing enables fast retrieval and browsing of molecular sequence databases.

    Conclusions:

    • GeneQuiz prototype demonstrates applicability in large-scale biological sequence analysis.
    • The system accelerates the process of identifying functional characteristics of proteins.
    • Automation and enhanced browsing significantly improve the efficiency of sequence analysis workflows.