Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Periodic sequence patterns in human exons

P Baldi1, S Brunak, Y Chauvin

  • 1Division of Biology, California Institute of Technology, Pasadena 91125, USA.

Proceedings. International Conference on Intelligent Systems for Molecular Biology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Measurement of Neutrino Oscillation Parameters with 10 Years of Data from the NOvA Experiment.

Physical review letters·2026
Same author

Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA.

Physical review letters·2025
Same author

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

Physical review letters·2024
Same author

Intrinsic polarity inversion in III-nitride waveguides for efficient nonlinear interactions.

Optics express·2023
Same author

Measurement of the ν_{e}-Nucleus Charged-Current Double-Differential Cross Section at ⟨E_{ν}⟩=2.4  GeV Using NOvA.

Physical review letters·2023
Same author

Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

The European physical journal. C, Particles and fields·2022
Same journal

Proceedings of the 8th International Conference on Intelligent Systems for Molecular Biology (ISMB 2000). San Diego, California, USA. August 19-23, 2000.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2001
Same journal

Analysis of gene expression data with pathway scores.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Mining for putative regulatory elements in the yeast genome using gene expression data.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Sequence database search using jumping alignments.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
See all related articles

Human exons exhibit a distinct periodic sequence pattern beyond their reading frame. This finding, uncovered using hidden Markov models, suggests a novel structural element in gene sequences.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Understanding the sequential structure of human genes is crucial for deciphering gene regulation and function.
  • Exons and introns play distinct roles in gene expression, with specific sequence features influencing these roles.

Purpose of the Study:

  • To analyze the sequential structure of human exons and their flanking introns.
  • To identify any periodic patterns within exon sequences beyond the established reading frame.

Main Methods:

  • Utilized hidden Markov models (HMMs) to analyze the sequential structure of human exons and flanking introns.
  • Developed models for donor site regions, acceptor site regions, and flanked internal exons.

Main Results:

Related Experiment Videos

  • Identified a specific periodic pattern within human exons, independent of the reading frame.
  • The observed pattern has a consensus of non-T(A/T)G and a minimal periodicity of approximately 10 nucleotides.
  • Ruled out nucleotide statistics at codon positions and nucleosome positioning signals as causes for this pattern.

Conclusions:

  • Human exons possess an intrinsic periodic sequence pattern.
  • This pattern may be related to other DNA sequence elements influencing DNA bending or curvature.
  • Further research is needed to elucidate the functional implications of this exonic periodic pattern.