Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A specification for defining and annotating regions of macromolecular structures

S E Brenner1, T J Hubbard

  • 1MRC Laboratory of Molecular Biology, Cambridge, England.

Proceedings. International Conference on Intelligent Systems for Molecular Biology
|January 1, 1995
PubMed
Summary

We developed a new standard for annotating macromolecular structures. This format facilitates data exchange and display across different computer systems, improving accessibility for researchers studying molecular structures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.

The pharmacogenomics journal·2016
Same author

The transcriptional landscape of the mammalian genome.

Science (New York, N.Y.)·2005
Same author

Effect of strength and proprioception training on eversion to inversion strength ratios in subjects with unilateral functional ankle instability.

British journal of sports medicine·2003
Same author

Prediction targets of CASP4.

Proteins·2002
Same author

Assessment of novel fold targets in CASP4: predictions of three-dimensional structures, secondary structures, and interresidue contacts.

Proteins·2002
Same author

Computational prediction of membrane-tethered transcription factors.

Genome biology·2002

Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational chemistry

Background:

  • Macromolecular structures are crucial for understanding biological processes.
  • Existing data formats for structural information can be system-dependent and difficult to share.
  • Standardization is needed for efficient communication and exchange of structural data.

Purpose of the Study:

  • To establish a program- and machine-independent standard for annotating macromolecular structures.
  • To enable seamless communication and exchange of structural information between diverse computational systems.
  • To define a format that specifies molecular display without relying on custom coordinate data formats.

Main Methods:

  • Development of a specification based on Abstract Syntax Notation One (ASN.1) objects.

Related Experiment Videos

  • Ensuring the format is mechanically straightforward to parse for computer systems.
  • Designing the format to be easily created and understood by human users.

    • Main Results:

    • A novel standard for macromolecular structure annotation has been created.
    • The format supports program and machine independence, enhancing data interoperability.
    • The specification includes guidelines for molecular visualization, independent of coordinate data formats.

    Conclusions:

    • The proposed standard offers a universal approach to annotating and sharing macromolecular structure data.
    • This format promotes greater accessibility and usability of structural information in research.
    • It simplifies data exchange and visualization, advancing the field of structural biology.