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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Immunospecific drug design--prospects for treatment of autoimmune diseases

R Arnon1, D Teitelbaum

  • 1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

Therapeutic Immunology
|January 1, 1994
PubMed

Recent advances in elucidating the activation and regulation of the autoimmune processes have provided new approaches for selective immunotherapy. Three different strategies are described: autoantigen-based therapy utilizing immunospecifically designed macromolecules and peptides, T-suppressor lines and clones, as well as antibodies specific to the antigen-MHC complex. These modalities, the efficacy of which has been demonstrated for experimental allergic encephalomyelitis, may be adapted to other experimental as well as human autoimmune diseases.

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