Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesterol and the coronary endothelium

C J Knight1, J B Warren

  • 1Department of Cardiology, Royal Brompton Hospital, London, UK.

Journal of Cardiovascular Risk
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A longitudinal interpretative phenomenological analysis study of athletes' lived experiences in elite disc golf competitions.

Scandinavian journal of medicine & science in sports·2024
Same author

Parent experiences of a remote patient monitoring program enabling early discharge from the neonatal intensive care unit with nasogastric tube feeding.

Journal of neonatal-perinatal medicine·2023
Same author

Informing the delivery of cancer survivorship care in rural primary care practice.

Journal of cancer survivorship : research and practice·2022
Same author

Use of enhanced stent visualisation compared to angiography alone to guide percutaneous coronary intervention.

International journal of cardiology·2020
Same author

Hazards of perioperative β-blockers are likely to be dose related.

British journal of anaesthesia·2015
Same author

Excessive range of statin dose in Western Australian primary care.

Internal medicine journal·2015
Same journal

Hair loss, insulin resistance, and heredity in middle-aged women. A population-based study.

Journal of cardiovascular risk·2003
Same journal

Alcohol use and cardiovascular disease preventive services.

Journal of cardiovascular risk·2003
Same journal

Clustering of cardiovascular risk factors and risk of development of hypertension in Japanese male office workers.

Journal of cardiovascular risk·2003
Same journal

Are heart disease patients more likely to have healthy lifestyle behaviors? Results from the 2000 Behavioral Risk Factor Surveillance Survey.

Journal of cardiovascular risk·2003
Same journal

Social relations in women with coronary heart disease: the effects of work and marital stress.

Journal of cardiovascular risk·2003
Same journal

Are anti-Chlamydia pneumoniae antibodies prognosis indicators for peripartum cardiomyopathy?

Journal of cardiovascular risk·2003
See all related articles

Atherosclerosis begins with cellular changes years before symptoms appear. Endothelial cells respond to chronic injury, like high cholesterol, triggering immune cell and platelet involvement.

Area of Science:

  • Cardiovascular Biology
  • Cellular Pathophysiology

Background:

  • Atherosclerosis pathogenesis involves early cellular events.
  • Chronic injury, particularly from hypercholesterolemia, initiates disease processes.

Purpose of the Study:

  • To elucidate the fundamental cellular mechanisms underlying atherosclerosis initiation.
  • To identify the role of endothelial cell responses in early atherogenesis.

Main Methods:

  • Focus on cellular events preceding clinical manifestation.
  • Analysis of endothelial cell responses to chronic injury.
  • Investigation of leucocyte and platelet activation, attachment, and migration.

Main Results:

  • Atherosclerosis originates from cellular events years before clinical symptoms.

Related Experiment Videos

  • Endothelial cell activation is a key response to chronic injury, such as hypercholesterolemia.
  • Leucocyte and platelet activation, attachment, and migration are critical early steps.

    • Conclusions:

    • The cellular basis of atherosclerosis is rooted in early responses to endothelial injury.
    • Understanding these cellular events is crucial for developing preventative strategies against atherosclerosis.