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Complement inhibitory therapeutics and xenotransplantation

U S Ryan1

  • 1T Cell Sciences, Inc., Needham, Massachusetts 02194, USA.

Nature Medicine
|September 1, 1995
PubMed

Once complement-mediated HAR has been inhibited, the full spectrum of cellular and antibody-mediated inflammatory and immune responses characteristic of acute and chronic rejection will need to be counter-manded. But the fact remains that if xenotransplantation is to become a clinical reality, a clinically relevant means of inhibiting complement activation will be required. Soluble complement receptor type 1 provides such a therapeutic option and an option where the dosing regimen is under the control of the physician and can be adjusted in response to the needs of the patient.

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