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Toxic and neurogenic factors in chloroquine myopathy fibre selectivity
E Velasco1, H J Finol, A Marquez
1Department of Histology and Embryology, Faculty of Medicine, Caracas, Venezuela.
Journal of Submicroscopic Cytology and Pathology
|October 1, 1995
Abstract:
Biopsies from soleus and extensor digitorum longus (EDL) muscles obtained in rats with an experimental chloroquine myopathy were studied ultrastructurally. Two different histopathological pictures were observed: type I fibres from soleus exhibited a vacuolar myopathy with an almost normal sarcomeric structure; type II fibres from EDL did not show vacuoles but changes similar to neurogenic atrophy. Our results suggest that chloroquine produces direct toxic effects in type I fibres and secondary neurogenic damage in type II fibres.