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Apical segmental dysfunction in hypertrophic cardiomyopathy: progression into end-stage heart failure with sudden

Y L Ko1, J L Lin, M H Lei

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.

Cardiology
|January 1, 1995
PubMed

Insights

Apical segmental dysfunction in hypertrophic cardiomyopathy (HCM) is rare but linked to poor outcomes. This condition may predict end-stage heart failure and sudden cardiac death risk in HCM patients.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • Apical segmental dysfunction is an uncommon echocardiographic finding in HCM.

Observation:

  • Two cases of HCM with apical segmental dysfunction presented with progressive apical dilatation.
  • Both patients developed congestive heart failure and died suddenly.
  • Intractable ventricular tachyarrhythmias were noted in one case during resuscitation.

Findings:

  • Apical segmental dysfunction in HCM is associated with a poor clinical course.
  • This subgroup of HCM patients faces a high incidence of malignant ventricular tachyarrhythmias.
  • The condition may indicate a predisposition to end-stage heart failure.

Implications:

  • Apical segmental dysfunction may serve as a prognostic marker in hypertrophic cardiomyopathy.
  • Identifying this subgroup can guide risk stratification and management strategies.
  • Further research is needed to clarify the long-term prognosis and therapeutic options.

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