Related Experiment Videos
Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean
M Kobayashi1, W Wang, N Ohyabu
1Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chemical & Pharmaceutical Bulletin
|September 1, 1995
Abstract:
An efficient asymmetric synthesis of a cyclic depsipeptide arenastatis A (1) is described. 1, isolated from the marine sponge Dysidea arenaria, exhibited extremely potent cytotoxicity with IC50 of pg/ml for KB cells, and in this context the structure-activity relationship among several stereoisomers of 1 and allied compounds has also been examined.