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Whipple's disease

G T Fantry1, S P James

  • 1Department of Medicine, University of Maryland, Baltimore, USA.

Digestive Diseases (Basel, Switzerland)
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Whipple's disease is a chronic infection affecting the small intestine, causing malabsorption and other systemic symptoms. Early diagnosis and a year of antibiotic treatment offer an excellent prognosis.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Whipple's disease is a chronic, systemic infectious disease caused by Tropheryma whippelii.
  • It primarily affects the small intestine, leading to malabsorption.
  • Extraintestinal manifestations like arthritis, fever, and CNS involvement are common.

Purpose of the Study:

  • To summarize the key aspects of Whipple's disease, including its clinical presentation, diagnosis, and treatment.
  • To highlight recent advances in understanding the pathophysiology and diagnosis of Whipple's disease.

Main Methods:

  • Diagnosis is confirmed by small intestine mucosal biopsy showing characteristic PAS-positive macrophages.
  • Treatment involves a 1-year course of trimethoprim-sulfamethoxazole.

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  • Molecular techniques are being used to identify Tropheryma whippelii.

    • Main Results:

    • Trimethoprim-sulfamethoxazole treatment typically leads to clinical remission.
    • The prognosis is generally excellent with appropriate treatment.
    • Molecular advancements promise a better understanding and potentially noninvasive diagnostic tests.

    Conclusions:

    • Whipple's disease requires prompt diagnosis and prolonged antibiotic therapy for successful management.
    • Ongoing research into Tropheryma whippelii is crucial for improving diagnostic accuracy and therapeutic strategies.