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Cerebral glucose utilization: local changes during and after recovery from spreading cortical depression
Science (New York, N.Y.)
|January 12, 1979
Summary
Spreading cortical depression significantly alters brain glucose metabolism, increasing it in the cortex while decreasing it in subcortical areas. Recovery shows sustained cortical glucose elevation, organized in vertical columns.
Area of Science:
- Neuroscience
- Cerebral Metabolism
Background:
- Spreading cortical depression (SCD) is a wave of neuronal and glial depolarization that propagates across the cerebral cortex.
- Understanding the metabolic consequences of SCD is crucial for comprehending brain function and dysfunction.
Purpose of the Study:
- To investigate the changes in cerebral glucose utilization during and after spreading cortical depression.
- To characterize the spatial distribution of metabolic activity during the recovery phase of SCD.
Main Methods:
- Utilized techniques to measure regional cerebral glucose utilization.
- Analyzed metabolic changes in both cortical and subcortical structures.
Main Results:
- Marked increase in cerebral glucose utilization in most cerebral cortex areas during SCD.
- Significant reduction in glucose utilization observed in many subcortical structures during SCD.
- Elevated cortical glucose utilization persists during recovery, exhibiting a columnar distribution perpendicular to the cortical surface.
Conclusions:
- Spreading cortical depression profoundly impacts brain energy metabolism.
- The recovery phase is characterized by a distinct, spatially organized metabolic reactivation in the cerebral cortex.