Related Experiment Videos
[Retinoid-selective ultraviolet phototherapy (SUP) in psoriasis]
Zeitschrift Fur Hautkrankheiten
|January 1, 1979
Summary
This study shows that combining oral retinoid (Ro 10-9359) with selective UV-phototherapy (SUP) effectively treats generalized psoriasis. Most patients achieved remission with minimal side effects, offering a practical outpatient treatment option.
Area of Science:
- Dermatology
- Photobiology
- Pharmacology
Context:
- Generalized psoriasis is a chronic inflammatory skin condition.
- Current treatments like systemic PUVA have limitations in practicability and side effects.
- Selective UV-phototherapy (SUP) utilizes specific UVA and UVB wavelengths.
Purpose:
- To evaluate the efficacy and safety of combining oral retinoid Ro 10-9359 with selective UV-phototherapy (SUP) for generalized psoriasis.
Summary:
- Twenty-seven patients with generalized psoriasis received oral Ro 10-9359 (50-75 mg/d) and daily SUP (UVA/UVB, 292.5-335 nm).
- Full remission was observed in 24 patients, with an average of 21.6 sessions over 5.3 weeks and a total energy of 68 J/cm2.
- Minor side effects like cheilitis and hair loss occurred in 4 patients.
Impact:
- The combined retinoid-SUP treatment demonstrated clinical efficacy comparable to systemic PUVA.
- This novel approach offers improved practicability and suitability for outpatient management of psoriasis.
- This study highlights a promising, well-tolerated therapeutic strategy for generalized psoriasis.