Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgG subclass levels in infancy and childhood

V A Oxelius

    Acta Paediatrica Scandinavica
    |January 1, 1979
    PubMed
    Summary

    This study tracked immunoglobulin G (IgG) subclass levels in children, finding they decrease in infancy and gradually increase with age, with adult levels not reached until puberty. IgG4 was undetectable in a notable percentage of older children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Antibody response to the Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in healthy and infection-prone individuals with IgG3 subclass deficiency.

    Journal of clinical immunology·2004
    Same author

    Imbalanced switch of the IGHG (immunoglobulin constant heavy G chain) Gm(bfn) genes in atopic childhood asthma.

    Allergy·2000
    Same author

    [Ataxia-telangiectasia surveyed in Sweden].

    Lakartidningen·2000
    Same author

    Serum Gm allotype development during childhood.

    Scandinavian journal of immunology·1999
    Same author

    Genetic B-cell variation based on immunoglobulin heavy G-chain (Gm) genes.

    Scandinavian journal of immunology·1999
    Same author

    Preparation of IgG subclass allotypes from polyclonal IgG.

    Scandinavian journal of immunology·1999

    Area of Science:

    • Immunology
    • Pediatric Medicine

    Background:

    • Immunoglobulin G (IgG) subclasses play crucial roles in immune defense.
    • Understanding the developmental trajectory of IgG subclasses is essential for assessing immune competence in children.

    Purpose of the Study:

    • To quantify and characterize the developmental patterns of IgG1, IgG2, IgG3, and IgG4 concentrations in healthy children from infancy through adolescence.
    • To establish age-specific reference ranges for IgG subclasses and compare them to adult levels.

    Main Methods:

    • Electroimmunoassay was employed to measure IgG subclass concentrations.
    • Maternal and cord sera (10 pairs) and sera from 162 healthy children (6 weeks to 15 years) were analyzed.
    • Specific rabbit antisera against IgG subclasses and a normal serum pool (WHO 67/97) as a reference were utilized.

    Main Results:

    • All IgG subclasses, except IgG4 in some cases, were detected in cord sera.
    • IgG subclass concentrations mirrored total IgG, showing a decline in the first 3-6 months, followed by a gradual increase with age.
    • IgG1 and IgG3 levels increased more rapidly than IgG2 and IgG4.
    • Adult levels were generally not attained before puberty.
    • IgG4 was undetectable in 12-21% of children over 7 years old.

    Conclusions:

    • The study provides normative data for IgG subclass development in children.
    • The findings highlight distinct developmental patterns among IgG subclasses, with implications for understanding immune maturation.
    • The transient absence of detectable IgG4 in a proportion of children warrants further investigation.

    Related Experiment Videos