Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Renal function in infants with hyperbilirubinemia

U Broberger, A Aperia

Acta Paediatrica Scandinavica

|January 1, 1979

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

p11 regulates the surface localization of mGluR5.

Molecular psychiatry·2015

Same author

Study of protein and RNA in dendritic spines using multi-isotope imaging mass spectrometry (MIMS).

Surface and interface analysis : SIA·2015

Same author

Alteration by p11 of mGluR5 localization regulates depression-like behaviors.

Molecular psychiatry·2015

Same author

Functional and molecular interactions between aquaporins and Na,K-ATPase.

Neuroscience·2009

Same author

Functional differences between D(1) and D(5) revealed by high resolution imaging on live neurons.

Neuroscience·2009

Same author

Glutamate-mediated calcium signaling: a potential target for lithium action.

Neuroscience·2009

Same journal

Atrial natriuretic peptide and renin-aldosterone relationship in healthy newborn infants.

Acta paediatrica Scandinavica·1991

Same journal

Adult panhypopituritarism presenting as idiopathic growth hormone deficiency in childhood: really idiopathic?

Acta paediatrica Scandinavica·1991

Same journal

Growth hormone therapy and final height in girls with Turner's syndrome.

Acta paediatrica Scandinavica·1991

Same journal

Mineral metabolism in obese children.

Acta paediatrica Scandinavica·1991

Same journal

Sex differences in vulnerability?

Acta paediatrica Scandinavica·1991

Same journal

Idiopathic dilatation of the aorta with dissection in a family without Marfan syndrome.

Acta paediatrica Scandinavica·1991

See all related articles

Infants with hyperbilirubinemia showed lower glomerular filtration rate (GFR) but similar conjugated plasma appearance rate (CPAH). Urinary sodium excretion was higher in these infants, indicating altered kidney function during neonatal jaundice.

Area of Science:

Neonatal medicine
Pediatric nephrology
Biochemistry

Background:

Neonatal hyperbilirubinemia is common and can affect various physiological systems.
Kidney function in infants with elevated bilirubin levels requires further investigation.

Purpose of the Study:

To assess glomerular filtration rate (GFR) and conjugated plasma appearance rate (CPAH) in infants with and without hyperbilirubinemia.
To evaluate the sodium excretion capacity in infants with neonatal jaundice.

Main Methods:

Comparison of 45 infants (term and preterm) based on serum bilirubin levels.
Determination of GFR and CPAH using the single injection clearance method.
Assessment of urinary sodium excretion after oral sodium chloride loading.

Related Experiment Videos

Main Results:

GFR was significantly lower in infants with hyperbilirubinemia, correlating negatively with peak bilirubin levels.
CPAH did not differ between infants with and without hyperbilirubinemia.
Urinary sodium excretion was significantly higher in infants with hyperbilirubinemia.

Conclusions:

Neonatal hyperbilirubinemia is associated with reduced GFR, suggesting impaired kidney filtration.
The ability to excrete sodium is increased in infants with hyperbilirubinemia, despite reduced GFR.
Further research is needed to understand the long-term implications of these renal changes.