[A clinical analysis of 15 cases of acute leukemia complicating pregnancy]

To explore the rational treatment program for acute leukemia complicating pregnancy, we carried out a retrospective study of 15 cases of acute leukemia complicating pregnancy and treated with chemotherapy from 1973 to 1993 in the Hematology Ward of PUMC. Review of the cases receiving chemotherapy revealed no harm to the children in cases of late onset and poor prognosis for the children in cases of early onset. However, the overall results seemed to indicate that the earlier the chemotherapy was instituted, the better the outcome will be for the mothers. A protocol is thus proposed with emphasis on the timing of institution of chemotherapy in relation to the course of pregnancy. Briefly, induced abortion followed by combined chemotherapy in early pregnancy and timely combined chemotherapy in mid- and late pregnancy are recommended. Brief cessation of chemotherapy during parturition may be necessary and sufficient supportive measures are needed.