Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spiral calcium waves: implications for signalling

P Camacho1, J D Lechleiter

  • 1Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

Ciba Foundation Symposium
|January 1, 1995
PubMed
Summary

Intracellular calcium (Ca2+) waves exhibit excitable medium properties, similar to neuronal electrical activity. This research reveals how Ca2+ wave dynamics encode information, with implications for cell signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilization of dissolved CO<sub>2</sub> to control methane and acetate production in methanation reactor.

Bioresource technology·2024
Same author

Necrotizing fasciitis attended in the Emergency Department in a tertiary Hospital: Evaluation of the LRINEC scale.

Revista espanola de cirugia ortopedica y traumatologia·2017
Same author

An emission processing system for air quality modelling in the Mexico City metropolitan area: Evaluation and comparison of the MOBILE6.2-Mexico and MOVES-Mexico traffic emissions.

The Science of the total environment·2017
Same author

Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment.

Cell death discovery·2016
Same author

MLVA typing of Mycoplasma hyopneumoniae bacterins and field strains.

Veterinary record open·2015
Same author

Optimization of municipal sludge and grease co-digestion using disintegration technologies.

Water science and technology : a journal of the International Association on Water Pollution Research·2012

Area of Science:

  • Cellular Biology
  • Biophysics
  • Physiology

Background:

  • Intracellular calcium (Ca2+) release plays a critical role in cellular signaling.
  • Ca2+ dynamics exhibit complex patterns, including spiral waves and wave annihilation.
  • Understanding these dynamics is key to deciphering cellular communication.

Purpose of the Study:

  • To investigate intracellular Ca2+ release using an excitable medium framework.
  • To explore the relationship between Ca2+ wave properties and cellular signaling.
  • To elucidate the mechanisms underlying Ca2+ wave propagation and information encoding.

Main Methods:

  • Modeling intracellular Ca2+ release as an excitable medium.
  • Analyzing spiral patterns of Ca2+ waves and their propagation velocity.
  • Investigating wave collision phenomena to identify refractory periods.
  • Examining the role of Ca2+-ATPases in regulating Ca2+ wave activity.

Main Results:

  • A direct relationship was found between increasing wavefront curvature and propagation velocity.
  • Ca2+ wave annihilation reveals an underlying refractory period.
  • Overexpression of sarco/endoplasmic reticulum Ca2+-ATPase increased Ca2+ wave activity frequency.
  • Propagation velocity showed a strong dependence on wavelength, aligning with excitability predictions.

Conclusions:

  • Intracellular Ca2+ release can be accurately modeled as an excitable medium, analogous to neuronal electrical excitability.
  • Ca2+ wave dynamics, including velocity and wavelength, are crucial for encoding cellular signals.
  • This framework provides new insights into how cells process and transmit information via Ca2+ signaling.

Related Experiment Videos