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[Phenprocoumon-induced cholestatic hepatitis]

S Woolley1, H R Burger, U Zellweger

  • 1Medizinische Abteilung des Regionalspitals Ilanz.

Deutsche Medizinische Wochenschrift (1946)
|November 3, 1995
PubMed
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Phenprocoumon, an anticoagulant, can cause rare cholestatic hepatitis, a liver condition characterized by jaundice. Eosinophilia in this case suggests an allergic reaction to the drug.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Immunology

Background:

  • Phenprocoumon is an anticoagulant used for thromboembolism prophylaxis.
  • Total knee prosthesis implantation is a common orthopedic procedure.
  • Hepatitis is a potential adverse effect of various medications.

Observation:

  • A 78-year-old woman developed cholestatic jaundice after receiving phenprocoumon following knee surgery.
  • Elevated bilirubin, transaminases, and eosinophils were noted.
  • Liver biopsy showed acute hepatitis with eosinophilic infiltration.

Findings:

  • Phenprocoumon was identified as the likely cause of the cholestatic hepatitis.
  • The presence of eosinophilia suggests an allergic hypersensitivity reaction.

Related Experiment Videos

  • Treatment with prednisone led to clinical improvement.

    • Implications:

    • This case highlights cholestatic hepatitis as a rare but serious side effect of phenprocoumon.
    • Physicians should consider drug-induced hypersensitivity in cases of unexplained hepatitis.
    • Monitoring for liver function is crucial in patients on long-term anticoagulation therapy.