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[Pathologic personality, temperament and treatment]

H S Akiskal

    L'Encephale
    |March 1, 1995
    PubMed
    Summary
    This summary is machine-generated.

    The link between mood disorders and personality disorders is debated, but some treatments show promise. Specific therapies and medications may help depressed patients with personality disorders.

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    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Neuroscience

    Context:

    • The relationship between affective disorders (e.g., depression) and personality disorders is complex and debated.
    • Treatment inefficacy for depressed patients with personality disorders may stem from inadequate therapeutic approaches.
    • A shared underlying substrate for these conditions is hypothesized based on clinical and experimental data.

    Purpose:

    • To explore the controversial relationship between affective and personality disorders.
    • To review therapeutic strategies for depressed patients with co-occurring personality disorders.
    • To examine evidence for a common biological or psychological basis for these conditions.

    Summary:

    • Clinical and experimental evidence suggests a potential common substratum linking affective and personality disorders.

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  • Specific pharmacological interventions, including lithium, neuroleptics, and monoamine oxidase inhibitors (MAOIs), show efficacy in certain borderline personality disorder cases with affective symptoms.
  • Pragmatic psychotherapies tailored to individual patient needs are also recommended.

    • Impact:

    • Highlights the need for tailored therapeutic approaches in treating comorbid affective and personality disorders.
    • Suggests potential pharmacological targets and psychotherapeutic strategies for improving patient outcomes.
    • Contributes to the understanding of the complex interplay between mood and personality pathology.