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Related Experiment Videos

A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute

M Fleshner1, T Deak, R L Spencer

  • 1Department of Psychology, University of Colorado-Boulder 80309, USA.

Endocrinology
|December 1, 1995
PubMed
Summary
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A single inescapable stressor event in rats can elevate basal corticosterone (CORT) levels for up to 96 hours. This stress exposure also alters corticotropin-binding globulin (CBG), increasing biologically active free CORT.

Area of Science:

  • Neuroendocrinology
  • Stress Physiology
  • Behavioral Neuroscience

Background:

  • Adrenal glucocorticoids, like corticosterone (CORT), are crucial mediators of stress responses.
  • Research has largely focused on acute stress-induced CORT elevations.
  • Chronic stress may alter basal CORT and corticotropin-binding globulin (CBG) levels.

Purpose of the Study:

  • To investigate if acute stress can induce long-term alterations in basal CORT and CBG.
  • To determine the persistence of these changes following stressor termination.

Main Methods:

  • Rats were exposed to a single session of inescapable tail shocks (IS).
  • Basal serum CORT and CBG levels were measured at various time points post-stress.
  • Measurements were taken during both diurnal peak (evening) and trough (morning) periods.

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Main Results:

  • A single IS session elevated basal total serum CORT for 48-96 hours post-stress.
  • This CORT increase was observed specifically during the morning trough.
  • CBG levels decreased for 24-48 hours, affecting both morning and evening measurements.
  • These alterations resulted in increased levels of biologically active free CORT.

Conclusions:

  • Acute stress can induce prolonged changes in basal CORT and CBG levels.
  • Elevated free CORT persists for several days after a single acute stressor.
  • These long-term changes in free CORT may contribute to the behavioral and physiological effects of acute stress.