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Updated: Aug 4, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Complexity of focal spikes suggests relative epileptogenicity
E Rodin1, M Litzinger, J Thompson
1Primary Children's Medical Center, University of Utah, Sandy, USA.
Abstract:
The EEGs of 39 children with focal or multifocal spikes were subjected to singular value decomposition (SVD) as provided by a commercial software program. We noted that in children with spikes but no clinical seizures the variance accounted for by the first component averaged 91.9%, whereas in children with seizures it was 68.0% (p < .001). The first component accounted for 85.4% in children with single spike foci, for 71.5% in those with multifocal spikes, and for 61.4% (p < 0.002) in those with both focal spikes and generalized spike-wave complexes. Spikes in the frontal and frontopolar areas were the most complex, suggesting that at least in children they tend to be the partial expression of a generalized seizure tendency rather than a result of strictly local pathology.
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