Related Experiment Videos
Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick
J Straczek1, F Maachi, D Le Nguyen
1Biochemistry Laboratory, Faculty of Medicine, University of Nancy I, Vandoeuvre, France.
FEBS Letters
|October 16, 1995
Abstract:
Human plasma has been shown to contain a low molecular weight factor that potentiates human IGF-I stimulation of glycosaminoglycan synthesis in chick embryo cartilage. The peptide was purified and characterized by Edman degradation and electrospray mass spectrometry. The primary structure determined was: Trp-Gly-His-Glu. A homologous synthetic peptide similarly promoted matrix biosynthesis in cartilage exposed to IGF-I.