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Related Experiment Videos

Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction

A LaBarre, H C Strauss, M M Scheinman

    Circulation
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Disopyramide can negatively impact sinus node function in patients with dysfunction, potentially causing serious pauses. Caution is advised, especially for those with existing sinus pauses or sinoatrial (SA) exit block.

    Area of Science:

    • Electrophysiology
    • Cardiology

    Background:

    • Sinus node dysfunction (SND) affects heart rhythm.
    • Disopyramide is an antiarrhythmic drug with potential electrophysiologic effects.

    Purpose of the Study:

    • To investigate the electrophysiologic effects of intravenous disopyramide on sinus node function in patients with SND.
    • To assess the impact of disopyramide on sinus cycle length, sinoatrial (SA) conduction, and sinus node recovery time.

    Main Methods:

    • 16 symptomatic patients with SND were studied.
    • Patients were divided into two groups based on ECG findings: sinus pauses/SA exit block (Group A) and sinus bradycardia (Group B).
    • Electrophysiologic parameters were measured before and after intravenous disopyramide administration (2 mg/kg).

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    Main Results:

    • Disopyramide altered spontaneous cycle length in most patients.
    • Estimated SA conduction time and maximum sinus node recovery time showed variable changes.
    • Two patients developed second-degree SA exit block; four patients experienced marked depression of sinus node function parameters.
    • P-wave, QRS durations, and H-V intervals were significantly prolonged.

    Conclusions:

    • Intravenous disopyramide can adversely affect sinus node function in patients with SND.
    • Particular caution is warranted in patients with sinus pauses, SA exit block, or secondary pauses.
    • Disopyramide administration requires careful consideration in this patient population.