Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The RNA polymerase II elongation complex

T Aso1, J W Conaway, R C Conaway

  • 1Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic cholecystectomy using the subserosal layer dissection technique in dogs: 34 cases (2015-2021).

The Journal of small animal practice·2022
Same author

Modification of LSC spectra of <sup>125</sup>I by high atomic number elements.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2018
Same author

Effect of inhomogeneity in a patient's body on the accuracy of the pencil beam algorithm in comparison to Monte Carlo.

Physics in medicine and biology·2012
Same author

Brain tissue water comes in two pools: evidence from diffusion and R2' measurements with USPIOs in non human primates.

NeuroImage·2012
Same author

Introduction and evaluation of computer-assisted education in an undergraduate dental hygiene course.

International journal of dental hygiene·2012
Same author

Dosimetric evaluation of nuclear interaction models in the Geant4 Monte Carlo simulation toolkit for carbon-ion radiotherapy.

Radiological physics and technology·2010

Regulation of eukaryotic gene expression occurs during transcription elongation by RNA polymerase II. New biochemical studies reveal diverse mechanisms and transcription factors controlling this process, challenging previous models of polymerase function.

Area of Science:

  • Molecular Biology
  • Gene Expression Regulation
  • Biochemistry

Background:

  • Eukaryotic gene expression is primarily regulated at transcription initiation by RNA polymerase II.
  • Emerging evidence highlights the elongation stage as a critical regulatory point.
  • The structure and catalytic mechanisms of RNA polymerase II are being re-evaluated.

Purpose of the Study:

  • To review recent insights into RNA polymerase II structure and function.
  • To discuss transcription factors regulating the elongation stage.
  • To explore novel mechanisms controlling eukaryotic messenger RNA synthesis.

Main Methods:

  • Biochemical studies
  • Analysis of transcription factor mechanisms
  • Review of structural and functional data for RNA polymerase II

Related Experiment Videos

Main Results:

  • Transcription elongation by RNA polymerase II is a major regulatory site.
  • Numerous transcription factors influence elongation through diverse mechanisms.
  • Unexpected features of RNA polymerase II challenge existing functional models.

Conclusions:

  • The elongation phase of transcription is a key regulatory target.
  • Understanding RNA polymerase II and its associated factors is crucial for gene expression control.
  • This review synthesizes current knowledge on elongation complex regulation.