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[Chronic viral hepatitis C. Anatomoclinical and biological correlations]
1Unité d'Hépatologie et de Gastroentérologie, Hôpital Saint-Antoine, Paris.
Gastroenterologie Clinique Et Biologique
|May 1, 1995
Summary
In chronic viral hepatitis C, elevated serum hyaluronic acid and alkaline phosphatase levels can non-invasively predict cirrhosis. These biomarkers help in diagnosing and monitoring liver disease progression.
Area of Science:
- Hepatology
- Biochemistry
Context:
- Chronic viral hepatitis C is a significant global health concern.
- Accurate staging of liver disease is crucial for patient management.
Purpose:
- To investigate the relationship between histopathological liver disease severity and clinical/biological data in 86 patients with chronic viral hepatitis C.
- To identify non-invasive biomarkers for predicting liver cirrhosis.
Summary:
- Patients with cirrhosis showed significant differences in biological parameters compared to those with less severe disease.
- Multivariate analysis identified alkaline phosphatase activity and serum hyaluronic acid as independent predictors of cirrhosis.
- Serum hyaluronic acid levels >150 µg/L or elevated alkaline phosphatase activity predicted cirrhosis with 87% sensitivity and 93% specificity.
Impact:
- Serum hyaluronic acid and alkaline phosphatase activity serve as valuable non-invasive indices for diagnosing and monitoring cirrhosis in chronic viral hepatitis C patients.
- These findings can aid in clinical decision-making and reduce the need for invasive procedures.
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