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Effects of vinca alkaloids on rat parotid and submandibular glands function in vivo
A R Dehpour1, P Ghafourifar, F Madani
1Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Iran.
Abstract:
1. Vincristine (1 mg/kg) and vinblastine (2 mg/kg) were injected intraperitoneally into the rats, 24 hr before the experiments. 2. Animals were anesthetized with 50 mg/kg of sodium pentobarbital and saliva was collected from vincristine-treated, vinblastine-treated and control animals using 8 mg/kg of pilocarpine as secretagogue. 3. Parotid saliva was analyzed for protein, amylase and Ca2+ content, and submandibular saliva for flow rate, protein and Ca2+ concentration. 4. Saliva from two treated groups was significantly lower (P < 0.01) in flow rate, amylase and protein content than that of control group. Calcium level was significantly increased (P < 0.05) in treated animals. 5. It is concluded that the antisecretory effects of vinca alkaloids may be consistent with their actions on salivary cell microtubules.