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Related Experiment Video

Updated: Feb 15, 2026

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The nocturnal polyuria syndrome (NPS)

R Asplund1

  • 1County Hospital, Strömsund, Sweden.

General Pharmacology
|October 1, 1995
PubMed
Summary

Nocturnal polyuria syndrome (NPS) causes increased nighttime urine output due to absent antidiuretic hormone (ADH) rhythms. Desmopressin effectively reduces nocturnal urine volume in elderly patients with NPS.

Area of Science:

  • Urology
  • Endocrinology

Background:

  • Nocturnal polyuria syndrome (NPS) is defined by elevated nighttime urine production.
  • This condition is linked to a lack of diurnal rhythm in the antidiuretic hormone (ADH) system, often with undetectable plasma ADH levels at night.
  • Individuals with NPS experience increased thirst, particularly at night, and frequent nighttime urination, leading to daytime fatigue.

Purpose of the Study:

  • To investigate the efficacy of desmopressin in reducing nocturnal urine output in elderly patients with NPS.

Main Methods:

  • A short-term study involved administering 20 micrograms of desmopressin via nose drops in the evening.
  • Another study utilized 40 micrograms of desmopressin as an intranasal aerosol in the evening for elderly NPS patients.

Main Results:

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  • Desmopressin treatment reduced nocturnal urine output from 65 +/- 8% to 50 +/- 15% of the 24-hour total in elderly NPS patients.
  • The studies indicate a significant reduction in nighttime urine volume following desmopressin administration.

Conclusions:

  • Desmopressin is an effective treatment for reducing increased nocturnal urine output in elderly individuals suffering from nocturnal polyuria syndrome.
  • Managing NPS with desmopressin can alleviate nighttime voiding frequency and improve daytime well-being.