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Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3
1Department of Molecular and Cell Biology, University of California at Berkeley 94720-3200, USA.
Gene
|October 3, 1995
Abstract:
The transcription factor GATA-3 contributes to the expression of several genes critical for T-cell function and development, including the T-cell receptor alpha and beta chains. We report here the isolation of a human cDNA clone which encodes a 3' segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact with GATA-3 in vitro. Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.