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Endocrine function of the peri- and postmenopausal ovary
1Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
Hormone Research
|January 1, 1995
Summary
The postmenopausal ovary retains secretory function, producing androgens like testosterone and moderate amounts of other steroids. Some ovaries may still secrete estradiol, contributing to estrogen levels through conversion.
Area of Science:
- Endocrinology
- Reproductive Biology
- Menopause Research
Background:
- The role of the postmenopausal ovary in hormone production is not fully understood.
- Investigating residual ovarian function is crucial for understanding menopausal endocrine changes.
Purpose of the Study:
- To quantify sex steroid concentrations in perimenopausal and postmenopausal women.
- To determine the secretory capacity of the postmenopausal ovary.
Main Methods:
- Blood samples were collected from peripheral and ovarian veins of 130 perimenopausal women.
- Concentrations of testosterone, androstenedione, estrone, dehydroepiandroepiandrosterone, and estradiol were measured.
Main Results:
- The postmenopausal ovary secretes significant amounts of testosterone and moderate levels of androstenedione, estrone, and dehydroepiandrosterone.
- While mean estradiol levels were low, some postmenopausal ovaries showed elevated estradiol (>50 pg/ml).
- Ovarian contribution to plasma androgens, subsequently converted to estrogens extragonadally, is suggested.
Conclusions:
- The postmenopausal ovary maintains some secretory function for estrone and estradiol.
- Ovarian androgen secretion plays a role in the overall estrogen pool via extragonadal conversion.
- Residual ovarian endocrine activity persists even after menopause.