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Bromocriptine inhibits norepinephrine release

M G Ziegler, C R Lake, A C Williams

    Clinical Pharmacology and Therapeutics
    |February 1, 1979
    PubMed
    Summary
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    Bromocriptine, a dopamine agonist, effectively lowers blood pressure by reducing norepinephrine release. This antihypertensive drug demonstrates efficacy in both central and peripheral mechanisms for managing sympathetic nervous activity.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cardiovascular Medicine

    Background:

    • Bromocriptine is a dopamine agonist with known antihypertensive properties.
    • It has been observed to induce postural hypotension.
    • The drug's mechanism involves the inhibition of norepinephrine release.

    Purpose of the Study:

    • To elucidate the antihypertensive mechanisms of bromocriptine.
    • To investigate bromocriptine's effect on norepinephrine (NE) release.
    • To assess the impact of bromocriptine on blood pressure in normotensive individuals.

    Main Methods:

    • Investigated the effect of bromocriptine on norepinephrine release from isolated arteries.
    • Stimulated presynaptic receptors to observe drug action.
    • Measured plasma and cerebrospinal fluid (CSF) NE levels in normotensive subjects.

    Related Experiment Videos

  • Monitored blood pressure in both standing and recumbent positions.

    • Main Results:

    • Bromocriptine inhibited norepinephrine release from isolated arteries.
    • Plasma and CSF levels of norepinephrine were reduced by 50% in normotensive subjects.
    • A moderate reduction in blood pressure was observed in standing subjects.
    • A slight reduction in blood pressure was noted in recumbent subjects.

    Conclusions:

    • Bromocriptine acts through central and peripheral mechanisms to inhibit sympathetic nervous discharge of norepinephrine.
    • The drug's ability to lower norepinephrine levels contributes to its antihypertensive effects.
    • Bromocriptine represents a potential therapeutic agent for managing blood pressure through modulation of the sympathetic nervous system.