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Related Experiment Video

Updated: Jul 11, 2026

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

Published on: May 11, 2011

Rapid adaptation to eccentric exercise-induced muscle damage

J Mair¹, M Mayr, E Müller

¹Department of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

International Journal of Sports Medicine

|August 1, 1995

Summary

This summary is machine-generated.

Eccentric exercise causes muscle damage, indicated by increased creatine kinase (CK) and myosin heavy chains (MHC). Repeated exercise leads to adaptation, reducing muscle soreness and biomarkers.

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Published on: August 31, 2022

Area of Science:

Exercise Physiology
Muscle Biology
Sports Medicine

Background:

Eccentric exercise is known to induce muscle damage.
Understanding the markers and adaptation patterns is crucial for training protocols.

Purpose of the Study:

To investigate muscle damage and adaptation following eccentric exercise.
To analyze the effects of repeated eccentric exercise bouts at different intervals.

Main Methods:

Twenty-two male subjects performed eccentric knee extensor exercise.
Muscle soreness, force generation (vertical jump), and plasma biomarkers (CK, MHC) were measured.
Exercise was repeated after 4 days (Group A) and 13 days (Group B).

Main Results:

Initial exercise increased CK and MHC, decreased muscle force, and caused soreness.
CK and MHC release correlated, but not with force reduction.
Repeated exercise after 13 days showed no significant damage markers or soreness.
Repeated exercise after 4 days abolished significant CK and MHC increases, with less soreness.

Conclusions:

Eccentric exercise causes slow-twitch skeletal muscle fiber injury.
Rapid adaptation occurs, significantly reducing muscle damage and soreness upon subsequent exercise bouts.
The timing of repeated exercise influences the adaptive response.