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Diabetic esophageal neuropathy and esophageal changes
1Research Institute of Nutrition, Bratislava, Slovakia.
Israel Journal of Medical Sciences
|November 1, 1995
Summary
Autonomic neuropathy (AN) significantly impacts esophageal function, often without clear symptoms. This study found AN in 93% of patients with peripheral neuropathy, revealing common, yet subtle, gastrointestinal changes.
Area of Science:
- Gastroenterology
- Neurology
- Internal Medicine
Background:
- Autonomic neuropathy (AN) is frequently underestimated, particularly its subclinical effects on esophageal motility.
- Peripheral neuropathy often coexists with undiagnosed autonomic dysfunction affecting visceral organs.
Purpose of the Study:
- To investigate the prevalence and clinical manifestations of esophageal autonomic neuropathy in patients with peripheral neuropathy.
- To characterize the specific radiographic and cardiorespiratory changes associated with AN in the esophagus.
Main Methods:
- Evaluated 36 non-obese subjects with diagnosed peripheral neuropathy using cardiorespiratory tests and radiographic esophageal studies.
- Assessed cholinergic and adrenergic functions and measured esophageal passage rate and lumen dimensions.
Main Results:
- Cardiorespiratory tests indicated AN in 93% of subjects.
- Radiographic findings included tertiary spasms (16.7%), inert esophagus (5.5%), and gastro-esophageal reflex (5.5%).
- Significant alterations in esophageal passage rate (P < 0.01) and lumen (P < 0.001) were observed compared to controls.
Conclusions:
- Autonomic neuropathy is highly prevalent in peripheral neuropathy patients, manifesting significantly in esophageal function.
- Esophageal involvement in AN is common but often clinically silent, necessitating further investigation beyond subjective complaints.