Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mutation of G proteins]

R M Trüeb1

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, USA.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pseudo-Fringe sign in frontal fibrosing alopecia-like cutaneous lupus erythematosus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Dystrophic calcinosis of the scalp from artificial hair implants: treatment with sodium metabisulfite.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Minoxidil-induced hypertrichosis in a breastfed infant.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Prepubertal pattern hair loss.

Clinical and experimental dermatology·2021
Same author

Comment on: folliculitis decalvans and lichen planopilaris phenotypic spectrum: a case report of two paediatric cases.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Male frontal fibrosing alopecia: study of 35 cases and association with sunscreens, facial skin and hair care products.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Guanine nucleotide-binding proteins (G proteins) act as cell membrane signal transducers. Mutations in G protein alpha-subunits can cause various diseases, with effects depending on mutation type and cellular distribution.

Area of Science:

  • Molecular biology
  • Cell signaling
  • Biochemistry

Context:

  • Guanine nucleotide-binding proteins (G proteins) are key signal transducers.
  • G protein-linked receptors relay diverse extracellular signals.
  • G proteins function as molecular switches regulated by GTPase cycles.

Purpose:

  • To explain the role of G proteins in cellular signal transduction.
  • To highlight the critical function of the G protein alpha-subunit (G alpha).
  • To discuss the consequences of G alpha mutations in disease.

Summary:

  • G alpha subunits bind guanine nucleotides and possess GTPase activity, regulating effectors.
  • Mutations in G alpha can lead to constitutive activation or loss of expression.
  • Abnormalities in G protein-coupled pathways are linked to diseases like blindness, hormone resistance, and neoplasia.

Related Experiment Videos

Impact:

  • Understanding G protein function is crucial for deciphering cellular communication.
  • G protein pathway defects offer insights into disease mechanisms.
  • The cellular distribution of affected components influences disease manifestation and localization.