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Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization
S Stella1, N Montanini, F Le Monnier
1Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano VA, Italy.
The Journal of Antibiotics
|August 1, 1995
Abstract:
GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.