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Chrysospermins, new peptaibol antibiotics from Apiocrea chrysosperma Ap101
K Dornberger1, W Ihn, M Ritzau
1Hans-Knöll-Institut für Naturstoff-Forschung, Jena, Germany.
The Journal of Antibiotics
|September 1, 1995
Summary
Four new peptaibol antibiotics, chrysospermins A-D, were discovered from Apiocrea chrysosperma. These novel nonadecapeptides show antibacterial and antifungal properties, and stimulate pigment production in Phoma destructiva.
Area of Science:
- Natural Product Chemistry
- Microbiology
- Medicinal Chemistry
Background:
- Peptaibol antibiotics are a class of peptides known for their biological activities.
- Apiocrea chrysosperma is a fungal species with potential for producing novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize new peptaibol antibiotics from Apiocrea chrysosperma.
- To evaluate the biological activities of the newly discovered compounds.
Main Methods:
- Isolation of compounds using solvent extraction, silica gel chromatography, and preparative recycling HPLC.
- Structure elucidation through detailed spectroscopic analysis and chemical degradation.
- Assessment of antibacterial, antifungal, and pigment-inducing activities.
Main Results:
- Four new nonadecapeptides, chrysospermins A, B, C, and D, were successfully isolated and structurally characterized.
- Chrysospermins A-D exhibited significant antibacterial and antifungal activities.
- The compounds were found to induce pigment formation in the fungus Phoma destructiva.
Conclusions:
- Apiocrea chrysosperma is a source of novel peptaibol antibiotics with potential therapeutic applications.
- Chrysospermins represent a new class of nonadecapeptides with diverse biological activities, including antimicrobial and pigment-inducing effects.