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Related Experiment Videos

Ontogeny of fever

K E Cooper, W L Veale, N Kasting

    Federation Proceedings
    |January 1, 1979
    PubMed
    Summary

    Newborn lambs and guinea pigs are resistant to bacterial pyrogens, suggesting immature thermoregulation or the presence of an endogenous antipyretic substance. This may explain the lack of fever in infected human neonates.

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    Area of Science:

    • Neonatal immunology
    • Comparative physiology
    • Thermoregulation

    Background:

    • Newborn lambs and guinea pigs exhibit refractoriness to bacterial pyrogens.
    • Fever response to bacterial endotoxin is limited in newborns, occurring only at high doses in guinea pigs.

    Purpose of the Study:

    • To investigate the mechanisms behind the lack of febrile response to endotoxin in newborn animals.
    • To explore potential reasons for fever unresponsiveness in neonates, including thermoregulatory immaturity or circulating antipyretic factors.

    Main Methods:

    • Comparative analysis of febrile responses to bacterial pyrogens in newborn sheep and guinea pigs.
    • Investigation into the production of endogenous pyrogens.
    • Examination of potential circulating antipyretic substances in newborn lambs and near-term ewes.

    Main Results:

    • Newborn lambs do not develop fever in response to bacterial pyrogens.
    • Newborn guinea pigs develop fever only with large doses of intravenous bacterial endotoxin.
    • Evidence suggests the presence of a circulating endogenous antipyretic substance in newborn lambs and near-term ewes.

    Conclusions:

    • The lack of febrile response to endotoxin in newborns occurs after endogenous pyrogen production.
    • This unresponsiveness may stem from immature central thermoregulatory mechanisms or the presence of endogenous antipyretic substances.
    • Findings may be relevant to understanding the lack of fever in infected human neonates.

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